Amphetamine is known to inhibit monoamine oxidase, While the ability of amphetamine and its metabolites to inhibit a variety of P450 isozymes and other enzymes hasn't been sufficiently elucidated. In vitro experiments with human microsomes reveal insignificant inhibition of CYP2D6 by amphetamine and insignificant inhibition of CYP1A2, 2D6, and 3A4